Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors
نویسندگان
چکیده
منابع مشابه
Growth-promoting properties of Epstein-Barr virus EBER-1 RNA correlate with ribosomal protein L22 binding.
The Epstein-Barr virus (EBV)-encoded RNAs, EBER-1 and EBER-2, are highly abundant noncoding nuclear RNAs expressed during all forms of EBV latency. The EBERs have been shown to impart significant tumorigenic potential upon EBV-negative Burkitt lymphoma (BL) cells and to contribute to the growth potential of other B-cell lymphoma-, gastric carcinoma-, and nasopharyngeal carcinoma-derived cell li...
متن کاملBinding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI.
Epstein-Barr virus encodes two small RNAs, EBER-1 and -2, that are abundantly expressed in latently infected cells. Recent evidence suggests a role for EBER-1 in regulation of translation since this RNA is able to prevent the inhibition of protein synthesis by double-stranded RNA in rabbit reticulocyte lysates. We show here that EBER-1 that has been synthesized in vitro forms a complex with the...
متن کاملReplacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells.
Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products also play a role in the growth of BL.
متن کاملAbbreviations: BM: bone marrow, CAEBV: chronic active Epstein-Barr virus infection, EBV: Epstein-Barr virus, EBER: Epstein-Barr virus-encoded mRNA, EBNA: Epstein-Barr virus-nuclear antigen, HLH: hemophagocytic lymphohistiocytosis, HIV: human immunodeficiency virus, HMB: hypersensitivity to mosquito
Affiliations: 1. Department of Pediatrics, 2. Department of Medicine and Biosystemic Science, 3. Department of Medicine, and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 4. Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo, 5. Department of 2 Pathology, Faculty of Medicine, Kurume University School o...
متن کاملExpression of Epstein-Barr virus-encoded small RNA (by the EBER-1 gene) in liver specimens from transplant recipients with post-transplantation lymphoproliferative disease.
BACKGROUND Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disease (PTLD) develops in 1 to 10 percent of transplant recipients, in whom it can be treated by a reduction in the level of immunosuppression. We postulated that the tissue expression of the small RNA transcribed by the EBER-1 gene during latent EBV infection would identify patients at risk for PTLD. MET...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2010
ISSN: 1476-4598
DOI: 10.1186/1476-4598-9-241